Hyaluronic acid (HA) is a natural polymer, which is found, above all, in connective tissues. It is mainly used for the treatment of joint pathologies and to reduce wrinkles as an injectable medical device.

But Hyaluronic Acid is naturally produced by our skin in a bid to maintain moisture levels. Thanks to pesky ageing and environmental aggressors, to name just a few things flung on a daily basis, those levels tend to take a bit of a dip.

Hyaluronic acid is found as a polymer with different molecular weights (high: HMW HA; low: LMW HA). In vitro studies have demonstrated that LMW HA – low weight – has a higher bioavailability, but is less resistant to hyaluronidase degradation.
Anti-inflammatory activity depends on the incubation time and from the polymer lenght.

These studies and literature data have brought to Full Spectrum Technology development, which consists of a specific HA spectrum of targeted defined molecular weights.
Particularly, one of the cosmetic product coming from this technology is PrincipHYAL® Cube3, which has shown in an ex vivo model of human reconstructed epidermis, to have a better absorption than the different molecular weights taken alone.

Find here the full article from Pharmanutrition and Functional Foods.