Acne is a multifactorial inflammatory skin disease affecting the quality of life of acne-prone subjects. Several therapeutic approaches are currently used to counteract this condition, mostly having side effects. As acne development has been recently linked to skin and gut dysbiosis, acting on both aspects could represent an alternative and promising approach to ameliorate the acne clinical signs.

Aim of the present study was to assess the effectiveness in the improvement of acne clinical signs of a novel In&Out combined acne treatment, composed by a cosmetic product containing Ectoin and a food supplement containing selected probiotic strains (L. plantarum PBS067, L. reuteri PBS072 and L. rhamnosus LRH020). In particular, the combined treatment (In&Out) was investigated for its skin improvement effect on adult subjects affected by acne through the reduction of the number and appearance of acne lesions (inflammatory and non-inflammatory acne).