Project Description
SynbiOFF
The “zombie” effect
Ingredient benefits
SynbiOFF line can early activate the immune cascade through the interaction with the innate immune system aiming to give a better response against infections. Heat-killed bacteria, preserving the cell shape, can inhibit pathogens adhesion and behave as a nutrient for commensal gut microbiota.
What is it?
SynbiOFF line is composed by heat-killed SynBalance® strains which have been inactivated through tyndallisation technique, a pasteurization-like process, which does not damage their membrane integrity.
What does it do?
SynbiOFF strains naturally rebalance the resident microbiota through the promotion of commensal bacteria growth as well as protection from pathogen adhesion and proliferation. They also maintain anti-inflammatory capacity comparable to corresponding viable strains.
Biological target
Increasing scientific findings link general wellness with gut homeostasis. Beyond alive probiotics, other complementary approaches can be put in place by inactivated bacteria such as prebiotic effect, molecular mimetism and also prevention from pathogens adhesion.
Mechanism of action
Heat-killed bacteria are reported to adhere to enterocytes-like cells by binding onto the microvilli. Their capacity to colonize gastro-intestinal epithelium leads to the inhibition of pathogens adhesion by steric hindrance. SynbiOFF strains also exert immune-modulation activity: they can activate pattern recognition receptors (PRRs) on the enteric cells in a pathogen-like manner, which promptly trigger innate immune cells and fine-tune adaptive immune response.
Benefits:
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