Mechanism of action
Heat-killed bacteria are reported to adhere to enterocytes-like cells by binding onto the microvilli. Their capacity to colonize gastro-intestinal epithelium leads to the inhibition of pathogens adhesion by steric hindrance. SynbiOFF strains
also exert immune-modulation activity: they can activate pattern recognition receptors (PRRs) on the enteric cells in a pathogen-like manner, which promptly trigger innate immune cells and fine-tune adaptive immune response.