Project Description

SynbiOFF

The “zombie” effect

Ingredient benefits

SynbiOFF line can early activate the immune cascade through the interaction with the innate immune system aiming to give a better response against infections. Heat-killed bacteria, preserving the cell shape, can inhibit pathogens adhesion and behave as a nutrient for commensal gut microbiota.

What is it?

SynbiOFF line is composed by heat-killed SynBalance® strains which have been inactivated through tyndallisation technique, a pasteurization-like process, which does not damage their mem­brane integrity.

What does it do?

SynbiOFF strains naturally rebalance the re­sident microbiota through the promotion of commensal bacteria growth as well as protec­tion from pathogen adhesion and prolifera­tion. They also maintain anti-inflammatory capacity comparable to corresponding viable strains.

Biological target

Increasing scientific findings link general wellness with gut homeostasis. Beyond alive probiotics, other complementary approaches can be put in place by inactivated bacteria such as prebiotic effect, molecular mimetism and also prevention from pathogens adhesion.

Mechanism of action

Heat-killed bacteria are reported to adhere to enterocytes-like cells by binding onto the mi­crovilli. Their capacity to colonize gastro-intestinal epi­thelium leads to the inhibition of pathogens adhesion by steric hindrance. SynbiOFF strains also exert immune-modula­tion activity: they can activate pattern recogni­tion receptors (PRRs) on the enteric cells in a pathogen-like manner, which promptly trigger innate immune cells and fine-tune adaptive immune response.

Benefits:

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