Project Description
SelectSIEVE® HopE
GLP-1 natural support
INGREDIENT BENEFITS
SelectSIEVE® HopE is the new ROELMI HPC's nutraceutical approach designed to support the management of obesity and metabolic syndrome.
It targets diabesity by reducing visceral fat (weight loss), improves insulin resistance (blood sugar levels management) and also reduces chronic inflammation. This makes it a game-changing ally for longevity and metabolic health.
Dosage: 200mg a day
Delivery forms: capsules, tablets, sachets, sticks, drinks, syrups, shakes, functional food.
What is it?
SelectSIEVE® HopE combines bioactive components from hop cones, obtained using advanced supercritical CO₂ extraction. The extract is then processed into a stable, easy-to-handle powder.
Highly rich in α and β acids, iso-α-acids, β-caryophyllene, and xanthohumol, it acts on the gut–liver axis,addressing simoultaneosly several core features of metabolic syndrome .
What does it do?
SelectSIEVE® HopE, exploits an integrated mechanism of action. It offers a comprehensive approach to prevent and manage metabolic syndrome, modulating key biochemical pathways in its complex pathophysiology.
Its multi-factorial approach makes it more effective than ingredients addressing single aspects of the condition, such as weight management, appetite and satiety balance, or insulin sensitivity.
For who it's interesting? For people who have high blood pressure, prediabetes, and are overweight or obese.
MECHANISM OF ACTION
SelectSIEVE® HopE bitter acids stimulate TAS2R bitter taste receptors in the intestinal epithelium. This triggers the release of GLP-1 and other enterohormones, such as CCK and PYY. These effects support weight management, increase satiety and reduce appetite.
In the liver, its iso-α-acids activate PPAR α and γ receptors. This improves insulin sensitivity, lowering blood sugar levels. It also supports a healthier blood lipid profile reducing LDL cholesterol and tryglicerides, while increasing HDL cholesterol.
AVAILABLE STUDIES
- GLP-1 release improvement
- Stimulation of CCK secretion
- Improvement in PYY release
- PPAR-α activation
- PPAR-γ agonism
BENEFITS
- Support for metabolic health
- Weight and visceral fat loss
- Blood sugar management
- Improvement of blood lipids profile
- Modulation of metabolic inflammation