Project Description

SelectSIEVE® Apple

From Earth, to protect your Heart


SelectSIEVE®Apple is composed of functional polyphenols, which act in a complementary manner through different metabolic pathways.

What is it?

SelectSIEVE®Apple is an active ingredient based on balanced and highly standardized polyphenols from apple.

What does it do?

SelectSIEVE® Apple components are reported to modulate glucose up-take and metabolism into the body.
They also positively influence the endothelial reactivity favoring a better blood flow and contribute to prevent CVD by bad cholesterol reduction.
These activities are useful for hyperglycemia prevention, carbohydrates in-take modulation and cardiovascular health.

Biological target

People affected by hyperglycemia or subjected to high risk of cardiovascular disease due to overweight.

Mechanism of action

  • Reduction of calories intake through competitive inhibition of intestinal glucose absorption due to the Phloridzinbond to the SGLT1/GLUT transporters
  • Regulation of hepatic glycaemia through modulation of the G6P-translocase activity by chlorogenicacid
  • Increase of draining through the improvement of blood circulation due to vasculoprotector and veinotonic action of flavonoids
  • Limitation of fat storage due to the repression of the PPAR-γ gene (differentiation of pre-adipocytes into mature adipocytes) then reducing fat storage
  • Metabolic effect by improving the endothelial reactivity and reducing the serum uric acid


  • Cardiovascular health
  • Elderly
  • Energy and sport
  • Weight management