Project Description
SelectSIEVE® Apple PCQ
The super fruit to modulate glycaemia
What is it?
SelectSIEVE®Apple PCQ is an active ingredient based on balanced and highly standardized polyphenols from apple.What does it do?
SelectSIEVE®Apple PCQ components are reported to modulate glucose up-take and metabolism into the body.They also positively influence the endothelial reactivity favoring a better blood flow and contribute to prevent CVD by bad cholesterol reduction.
These activities are useful for hyperglycemia prevention, carbohydrates in-take modulation and cardiovascular health.
Biological target
People affected by hyperglycemia or subjected to high risk of cardiovascular disease due to overweight.Mechanism of action
- Reduction of calories intake through competitive inhibition of intestinal glucose absorption due to the Phloridzinbond to the SGLT1/GLUT transporters
- Regulation of hepatic glycaemia through modulation of the G6P-translocase activity by chlorogenicacid
- Increase of draining through the improvement of blood circulation due to vasculoprotectorand veinotonicaction of flavonoids
- Limitation of fat storage due to the repression of the PPAR-γ gene (differentiation of pre-adipocytes into mature adipocytes) then reducing fat storage
- Metabolic effect by improving the endothelial reactivity and reducing the serum uric acid
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