Project Description

PrincipHYAL® Difference

A difference you can feel


PrincipHYAL® Difference decreases skin wrinkles, increases skin elasticity, smoothness, wrinkleness, diminishes roughness, scaliness & number of wrinkles. Global epidermis health is improved, like moisturization, barrier effect and skin aspect.


Sodium Hyaluronate is a linear polymer characterized by an ensemble of parameters in which molecular weight plays an important role.
However, PrincipHYAL® Difference is based on a specific spectrum of molecule lengths.
It is the direct result of the evolution of skin complexity at mature state, miming a range of fractions working in synergy, just as naturally found in our body.

What is it?

PrincipHYAL® Difference is a full-spectrum biotechnological fraction of sodium hyaluronate that targets long-term anti-aging effects.

What does it do?

PrincipHYAL® Difference improves skin aspect (less wrinkles, smoothed, more elastic, hydrated and rejuvenated), skin moisturization, skin barrier effect, and also helps to diminish the consequences of oxidation.

Biological target

Mature or aging skins are directly related to the appearance of deeper wrinkles. Internal oxidative processes that affect cells integrity deregulate the rejuvenation cycles. PrincipHYAL® Difference is a biotechnological ingredient that reproduces a specific spectrum of molecular weight, with a targeted focus on skins at a particular physiological step (homeostasis or stress).

Mechanism of action

Treated skins react in a more adapted manner, thanks to an evolutive interaction between matrix hyaluronans and their cell receptor CD44. This adaptive answer gives to the cell a capacity to “sense” its microenvironment and respond in return (by signal transduction or by cytoskeletal dynamics regulation). The benefit for final consumers? A better effect linked to a more specific cellular answer.


  • Anti-oxidation
  • Anti-wrinkles / Preage
  • Hydration (long term)
  • Matrix degradation